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Although systemic administration routes (e.g., intravenous or oral), have served as the cornerstone of treatment of lung cancer, they face critical bottlenecks, such as blood-air barrier, extremely low drug accumulation in tumor site, and pronounced systemic toxicity [54]

Acknowledgements We thank Sawako Suzuki (Chiba University) and Hideaki Bujo (Toho University) for helpful advice during the course of the study

L-Carnitine helps to increase the body's oxygen uptake and reduces muscle fatigue

Results of this trial were remarkably similar to those of the pivotal etanercept and infliximab trials